Research Compound Comparison
Semax vs Selank
Semax (MEHFPGP) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) are two synthetic peptides studied for neurobiological and cognitive research. Semax is an ACTH(4-7) analog that upregulates BDNF and NGF for neurotrophic pathway research. Selank is a tuftsin analog that modulates GABAergic and enkephalin pathways for anxiolytic and stress-response research. Both have similar molecular weights and plasma half-lives but operate via distinct neurobiological mechanisms.
| Parameter | Semax | Selank |
|---|---|---|
| Category | Cognitive | Cognitive |
| Primary Receptor / Target | BDNF / NGF upregulation | GABAergic / Enkephalin |
| Half-Life | ~1–2 min plasma (intranasal model) | ~1–2 min plasma (intranasal model) |
| Molecular Weight | 813 Da | 863 Da |
| HPLC Purity | Not published | Not published |
| COA | Batch-Specific | Batch-Specific |
| Price | On request | On request |
Mechanistic Comparison
Semax — Neurotrophic Signaling via BDNF/NGF
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a heptapeptide synthetic analog of ACTH(4-7). Its primary research mechanism involves upregulation of BDNF (Brain-Derived Neurotrophic Factor) and NGF (Nerve Growth Factor). BDNF activates TrkB receptors to promote neuronal survival, synaptic plasticity, and neurogenesis. Semax also modulates dopaminergic and serotonergic neurotransmitter systems. Research applications focus on neuroplasticity studies, cognitive performance models, neuroprotection research, and neurotrophic signaling investigations.
Selank — GABAergic Modulation and Enkephalin Pathway
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of tuftsin. Its primary research mechanism involves modulation of GABAergic neurotransmission and inhibition of enkephalin-degrading enzymes, increasing endogenous enkephalin availability. Selank also affects serotonin transport gene expression. Research applications focus on anxiolytic pathway studies, stress-response mechanism research, GABAergic modulation models, and behavioral research designs.
Complementary Neurobiological Pathways
Semax and Selank address different neurobiological pathways. Semax operates via neurotrophic upregulation — structural and functional neuroplasticity via BDNF/NGF. Selank operates via neurotransmitter modulation — GABAergic tone and enkephalin availability. These are complementary: Semax for neurotrophic support, Selank for inhibitory neurotransmitter modulation.